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目的 应用动态血压监测法 ,评价卡维地洛对原发性高血压患者的疗效。方法 2 0例WHOI～II期原发性高血压患者 ,经安慰剂洗脱 2周后 ,口服卡维地洛 4周 ,剂量为 2 0～ 40mg/d ,一次服。治疗前后用动态血压监测仪 (Spacelab 90 2 0 7型 )各测 1次动态血压 ,并计算谷 /峰 (T/P)比值。结果卡维地洛主要降低白天血压 ,收缩压 (SBP)和舒张压 (DBP)分别下降8 2 %和 8 5 %。对夜间血压降压作用不明显 ,清晨血压基本回复治疗前水平。卡维地洛给药后心率减慢 ,降低幅度也是白天大于夜间。 2 0例病例中 ,有效病例 9例 ,SBP和DBP的T/P比值分别为 6 1 3%和 39 8% ,未达到美国食品与药品管理局(FDA)对每日一次给药的降压药规定的T/P比值标准。结论卡维地洛能有效地控制白天血压 ,但在清晨降压作用不明显。建议给药剂量最好每日两次 ,每次 10～ 2 0mg
Objective To evaluate the efficacy of carvedilol in patients with essential hypertension by using ambulatory blood pressure monitoring. Methods Twenty two patients with WHOI ~ II essential hypertension were given Carvilliram orally for 2 weeks after 2 weeks of placebo. The dose was 20 ~ 40mg / d once a day. Before and after treatment with ambulatory blood pressure monitor (Spacelab 90 2 0 7 type) each measured 1 ambulatory blood pressure and calculate the valley / peak (T / P) ratio. Results Carvedilol mainly reduced blood pressure at daytime, and systolic blood pressure (SBP) and diastolic blood pressure (DBP) decreased by 82% and 85%, respectively. Blood pressure at night is not obvious antihypertensive effect, early morning blood pressure basic level before treatment. Carvedilol slowed down after administration, the reduction is greater than during the daytime night. Among 20 cases, 9 cases were effective, and the T / P ratios of SBP and DBP were 61.3% and 39.8%, respectively, which did not reach the level of blood pressure lowering once a day by the U.S. Food and Drug Administration Drug prescribed T / P ratio standards. Conclusion Carvedilol can effectively control the blood pressure during the day, but the antihypertensive effect is not obvious in the early morning. Recommended dosage is best twice daily, each 10 ~ 20mg