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本文报导非淋巴网细胞淋巴瘤348例其中24例经证实有中枢神经系统的侵犯。此24例中,弥漫型组织细胞淋巴瘤7例、未分化淋巴瘤3例、弥漫型低分化淋巴细胞淋巴瘤9例(其中转变为白血病6例)、结节型低分化淋巴细胞淋巴瘤5例。中枢神经系统病变临床表现:颅神经瘫痪15例,嗜睡和昏睡、头痛各10例,两下肢无力6例,精神变化5例,感觉异常4例,颈项强直、划蹠试验阳性、瘫痪各3例,运动失调、惊厥、昏迷各2例,膀胱和肠功能紊乱、背痛各1例。神经病理发现:尸检21例,有软脑膜侵犯17例,一般范围广泛,偶见浸润局限于小脑或大脑的脑膜,在邻近脑实质同时合并有血管周围侵犯14例,单个或多个大的脑实质浸润4例,硬脑膜斑片状或灶状侵犯7例,后神经根浸润3例,室管膜下有显微镜下小的灶性浸润2例。此外,大脑半球皮质表面有多发性点状出血5例(均伴有血小板减少),脑水肿7例。有4例结节型低分化淋巴细胞淋巴瘤尸检时发现是弥漫型。
This article reports 348 cases of non-lymphocytic cell lymphoma, of which 24 cases have been proven to have violations of the central nervous system. Among the 24 cases, 7 were diffuse histiocytic lymphoma, 3 were undifferentiated lymphoma, 9 were diffusely differentiated lymphocytic lymphoma (6 were converted to leukemia), 5 were poorly differentiated lymphoid lymphoma example. Clinical manifestations of central nervous system lesions: cranial nerve paralysis in 15 cases, lethargy and lethargy, headache in 10 cases, two limbs weakness in 6 cases, mental changes in 5 cases, 4 cases of sensory abnormalities, cervical rigidity, plantar test was positive, paralysis in 3 cases , Motor disorders, convulsions, coma in 2 cases, bladder and bowel disorders, back pain in 1 case. Neuropathological findings: autopsy in 21 cases, there are 17 cases of pia mater invasion, the general scope of a wide range of occasional infiltration limited to the cerebellum or brain of the meninges, in the adjacent brain parenchyma with perivascular invasion of 14 cases, single or multiple large brain 4 cases of real infiltration, dura patchy or focal lesions in 7 cases, 3 cases of nerve root infiltration after subependymal under the microscope with small focal infiltration in 2 cases. In addition, the hemispheric cortex in the surface of multiple punctate bleeding in 5 cases (both associated with thrombocytopenia), cerebral edema in 7 cases. 4 cases of nodal poorly differentiated lymphoid lymphoma autopsy found to be diffuse.