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目的 观察甲亢、甲减患者血清骨钙素 (BGP)含量 ,探讨甲状腺功能异常与骨代谢的关系。方法 测定 4 0例甲亢患者 ,2 0例甲减患者血清 BGP及甲状腺激素含量 ,并与 30例正常对照组比较。结果 甲亢患者血清 BGP含量明显高于正常对照组 (P<0 .0 1) ,甲减患者血清 BGP含量明显低于正常对照组 (P<0 .0 1) ,BGP的含量与甲状腺激素 (FT3 、FT4 )显著正相关 ,与 s TSH显著负相关 ,与性别无明显相关。结论 甲亢患者甲状腺激素增高可使成骨细胞活性增加 ,骨转换加快 ,而甲减患者则骨形成减少 ,BGP含量可作为观察甲状腺疾病患者骨病的敏感指标。
Objective To investigate the serum BGP in patients with hyperthyroidism and hypothyroidism and to explore the relationship between abnormal thyroid function and bone metabolism. Methods Serum levels of BGP and thyroid hormone in 40 patients with hyperthyroidism and 20 patients with hypothyroidism were measured and compared with 30 healthy controls. Results Serum BGP levels in patients with hyperthyroidism were significantly higher than those in normal controls (P <0.01). Serum BGP levels in patients with hypothyroidism were significantly lower than those in normal controls (P <0.01) , FT4) was significantly positive correlation, and s TSH significant negative correlation with gender no significant correlation. Conclusion Thyroid hormone increased in hyperthyroid patients can increase the activity of osteoblasts, bone turnover accelerated, while hypothyroidism decreased bone formation, BGP content can be used as a sensitive indicator of bone disease in patients with thyroid disease.