氟康唑为口服有效的抗真菌新药。在全身真菌感染的动物模型中,其效力是酮康唑的5～100倍,而与静注两性霉素B 相似。本品口服吸收良好,人血浆t_(1/2)接近28 h。分布容积0.75 L/kg 组织,脑脊液、唾液浓度数据均表明本品在体液中分布均匀。一些真菌病常累及肺,因此,为了评价肺部感染时氟康唑的可用性,作者在11名稳定脓性支气管扩张病人 Fluconazole is an orally effective antifungal drug. In animal models of systemic fungal infections, its potency is 5 to 100 times that of ketoconazole, similar to amphotericin B iv. This product is well absorbed orally, human plasma t_ (1/2) close to 28 h. Distribution volume 0.75 L / kg tissue, cerebrospinal fluid, saliva concentration data show that the goods in the body fluid distribution. Some fungal diseases often involve the lungs, therefore, in order to evaluate the availability of fluconazole in lung infections, the authors of 11 patients with stable purulent bronchiectasis