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目的 研究Survivin基因在食管癌中的表达与生物学特性的关系。方法 免疫组织化学法检测 62例食管癌组织及癌旁正常组织Survivin的表达。结果 食管癌组织Survivin阳性表达率为 79 0 % ,显著高于癌旁正常组织 ( 6 5 % ,P <0 0 1) ,低分化、中分化、高分化癌组织阳性率无差异 (P >0 0 5 ) ,淋巴结转移组阳性率为 93 1% ,高于无淋巴结转移组的阳性率 ( 66 7% ,P <0 0 5 )。结论 Survivin基因在食管癌中高表达 ,与淋巴结转移呈正相关 ,但与癌组织分化程度无关。
Objective To study the relationship between the expression of Survivin gene and biological characteristics in esophageal cancer. Methods Immunohistochemistry was used to detect the expression of Survivin in 62 cases of esophageal cancer tissues and adjacent normal tissues. Results The positive expression rate of Survivin in esophageal cancer tissues was 79 0%, which was significantly higher than that in adjacent normal tissues (65%, P 0 01). There was no difference in the positive rate of survivin between poorly differentiated and well differentiated cancers The positive rate of lymph node metastasis was 93.1%, which was higher than that of no lymph node metastasis (66.7%, P <0.05). Conclusion Survivin gene is overexpressed in esophageal cancer and positively correlated with lymph node metastasis, but it has no relation with the degree of differentiation.