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探讨细胞因子 IL-1 ,IL-6,IL-8,TNF-α与胎儿宫内窘迫的关系及对分娩方式和产程长短的影响 .选择妊娠期正常、孕龄在 3 7周和 42周之间的单胎新生儿 1 2 8例 ,收集脐血样本 .将 1 2 8例按有无胎儿宫内窘迫及分娩方式分为 4组 ,采用免疫放射分析法测定 IL -1 ,IL-6,IL-8及 TNF-α.从产程的长短及分娩方式进行对比分析 ,并观察胎儿宫内窘迫脐血中细胞因子水平与 p H之间是否存在相关关系 .有无胎儿窘迫都不影响 IL-1脐血水平 .有胎儿宫内窘迫组的 IL-6和 IL-8水平显著高于无胎儿宫内窘迫组 (分别为 P=0 .0 1和 P<0 .0 0 1 ) ,而 TNF-α脐血水平显著降低 ( P<0 .0 0 1 ) .分娩可增加 IL-8,但对 IL-6水平没有影响 .若胎儿宫内窘迫与分娩因素并存 ,则能增加 IL-6和 IL-8水平 ,但 TNF-α水平降低 .细胞因子与 p H之间无相关关系 .胎儿宫内窘迫组 IL-6和 IL-8水平显著高于无胎儿宫内窘迫组 ,而 TNF-α脐血水平显著降低 .细胞因子与 p H之间无相关关系 .
To investigate the relationship between cytokine IL-1, IL-6, IL-8, TNF-α and fetal distress and their effects on the mode of delivery and the length of labor.Select gestational normal, gestational age at 37 weeks and 42 weeks One hundred and twenty-eight newborn infants were enrolled in this study, and cord blood samples were collected.128 cases were divided into 4 groups according to the presence or absence of fetal distress and mode of delivery, and the levels of IL-1, IL-6, IL-8 and TNF-α were compared between labor and delivery mode, and whether there was a correlation between the level of cytokines and p H in fetal umbilical distress umbilical cord blood.With or without fetal distress did not affect IL- IL-6 and IL-8 levels in fetal distress group were significantly higher than those in non-fetal distress group (P = 0.01 and P <0.01, respectively), whereas TNF α-cord blood levels were significantly lower (P <0.01) .If delivery can increase IL-8, but has no effect on IL-6 levels.If fetal distress and childbirth factors co-exist, can increase IL-6 and IL-8, IL-8 and TNF-α, but there was no correlation between cytokines and p H. The levels of IL-6 and IL-8 in fetal distress group were significantly higher than those without fetal distress group, Umbilical Levels were significantly reduced. No correlation between cytokine and p H.