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目的评价盐酸丁咯地尔(Buflomedil Hydrochloride)联合尿激酶(UK)治疗急性下肢深静脉血栓(DVT)的临床疗效。方法前瞻性地将70例急性下肢DVT患者随机分为两组,实验组(60例)经患肢足背浅静脉予以盐酸丁咯地尔(莱斯多维)联合UK治疗,对照组(60例)经患肢足背浅静脉予以UK治疗。以下肢肿胀消退及下肢深静脉造影评价治疗效果。结果实验组治疗后第3、7、10天患肢消肿率分别为(76±5)%、(91±11)%、(95±7)%,对照组分别为(51±8)%、(72±5)%、(92±10)%。第3、7天消肿率实验组明显高于对照组,差异有统计学意义(P<0.05)。实验组溶栓率为(78±18)%,对照组溶栓率为(72±21)%,差异无统计学意义(P>0.05)。两组患者均无严重并发症发生。结论盐酸丁咯地尔联合尿激酶联合治疗急性下肢深静脉血栓可明显提高患肢消肿率。
Objective To evaluate the clinical efficacy of Buflomedil Hydrochloride in combination with urokinase (UK) in the treatment of acute lower extremity deep vein thrombosis (DVT). Methods A total of 70 acute DVT patients with acute lower extremity were prospectively divided into two groups. The experimental group (60 cases) received buflomedil hydrochloride combined with UK via limbal superficial dorsal vein. The control group (60 cases ) By the limb dorsal superficial vein to UK treatment. Subcutaneous swelling and lower extremity deep vein angiography to evaluate the therapeutic effect. Results The swelling rate of limbs in the experimental group was (76 ± 5)%, (91 ± 11)% and (95 ± 7)% on the 3rd, , (72 ± 5)%, (92 ± 10)%. On the 3rd and 7th day, the swelling rate in the experimental group was significantly higher than that in the control group, the difference was statistically significant (P <0.05). The rate of thrombolysis in the experimental group was (78 ± 18)% and in the control group was (72 ± 21)%, the difference was not statistically significant (P> 0.05). No serious complications occurred in both groups. Conclusion Buflomedil hydrochloride combined with urokinase in the treatment of acute lower extremity deep venous thrombosis can significantly improve the limb swelling.