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目的探讨大剂量丙种球蛋白联合干扰素治疗重症小儿手足口病并发病毒性脑炎的临床疗效。方法将手足口病合并病毒性脑炎患儿184例随机分为研究组和对照组各92例。对照组在常规基础上给予干扰素进行治疗,研究组在常规基础上给予大剂量丙种球蛋白联合干扰素进行治疗。治疗后比较2组临床疗效和临床症状缓解时间。结果研究组总有效率明显高于对照组,体温恢复正常时间、皮疹消退时间、头痛缓解时间、呕吐缓解时间、精神状态好转时间均短于对照组,差异有统计学意义(P<0.01)。结论大剂量丙种球蛋白联合干扰素治疗重症小儿手足口病并发病毒性脑炎效果较好,明显缩短治疗时间,不良反应较少,安全性较高,具有较高临床应用价值。
Objective To investigate the clinical efficacy of high-dose gamma globulin combined with interferon in the treatment of severe infantile hand-foot-mouth disease with viral encephalitis. Methods 184 cases of hand, foot and mouth disease with viral encephalitis were randomly divided into study group and control group, 92 cases each. The control group was treated with interferon on a routine basis. The study group was given high-dose gamma globulin combined with interferon on a routine basis. After treatment, the clinical efficacy and clinical symptom relief time were compared between the two groups. Results The total effective rate of the study group was significantly higher than that of the control group. The recovery time of normal body temperature, rash subsidence time, headache relief time, vomiting relief time and mental state improvement time were all shorter than those of the control group (P <0.01). Conclusion High-dose gamma-globulin combined with interferon is effective in treating HFMD complicated by viral encephalitis in children with severe pediatric disease. It significantly shortens the treatment time, has fewer adverse reactions, is more safe and has higher clinical value.