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目的检测子宫内膜异位症(EMs)患者和对照组腹腔液中IGF-Ⅰ和PAPP-A的水平变化及相关性,探讨其在子宫内膜异位症发病机制中的作用。方法采用酶联免疫吸附法(ELISA)检测39例内异症患者(EMs组)及25例非内异症患者(对照组)腹腔液中IGF-Ⅰ和PAPP-A水平。结果①EMs组中,IGF-Ⅰ和PAPP-A水平分别为(117.1±36.6)ng/L、(2.85±0.56)ng/mL,均高于对照组的(79.5±18.7)ng/L、(1.93±0.56)ng/mL(P<0.05);②Ⅲ～Ⅳ期患者腹腔液中IGF-Ⅰ水平为(126.5±39.1)ng/L高于Ⅰ～Ⅱ期患者的(107.3±32.0)ng/L(P>0.05),而Ⅲ～Ⅳ期患者腹腔液中PAPP-A水平为(3.15±0.50)ng/mL高于Ⅰ～Ⅱ期患者的(2.55±0.45)ng/mL(P<0.05),且PAPP-A水平与r-AFS评分呈正相关;③EMs患者腹腔液中PAPP-A和IGF-Ⅰ水平无显著相关性(P>0.05)。结论腹腔液中IGF-Ⅰ和PAPP-A的增高可能与内异症的发病有关;PAPP-A与疾病的严重程度有关。
Objective To detect the levels of IGF-Ⅰ and PAPP-A in patients with endometriosis (EMs) and control group, and to explore its role in the pathogenesis of endometriosis. Methods The levels of IGF-Ⅰ and PAPP-A in peritoneal fluid of 39 patients with endometriosis (EMs group) and 25 patients with non-endometriosis (control group) were detected by enzyme linked immunosorbent assay (ELISA). Results ① The levels of IGF-Ⅰ and PAPP-A in the EMs group were (117.1 ± 36.6) ng / L and (2.85 ± 0.56) ng / mL, respectively, higher than those in the control group (79.5 ± 18.7 ng / L, 1.93 ± 0.56) ng / mL (P <0.05). The level of IGF-Ⅰ in peritoneal fluid of patients with stage Ⅲ-Ⅳ was (126.5 ± 39.1) ng / L higher than that of stage Ⅰ-Ⅱ patients (107.3 ± 32.0) ng / L (P> 0.05). The level of PAPP-A in peritoneal fluid of patients with stage Ⅲ ~ Ⅳ was (3.15 ± 0.50) ng / mL higher than that of stage Ⅰ ~ Ⅱ patients (2.55 ± 0.45) ng / mL There was a positive correlation between PAPP-A level and r-AFS score. ③ There was no significant correlation between PAPP-A level and IGF-Ⅰ level in EMs patients (P> 0.05). Conclusion The increase of IGF-Ⅰ and PAPP-A in peritoneal fluid may be related to the pathogenesis of endometriosis. PAPP-A is related to the severity of the disease.