目的探讨外科清洁手术围手术期合理使用抗生素的问题。方法通过外科临床药师在下临床过程中积累经验,总结清洁手术围手术期合理使用抗生素的体会及建议。结果围手术期抗生素使用存在不合理现象,主要表现在无指证用药,用药时机选择不当,术后用药时间偏长。结论抗生素在预防术后感染、增加手术安全性、提高治愈率方面作用明显,但如不能合理地使用,也会带来不良反应。临床药师应更好地辅助临床医师围手术期合理使用用抗生素。 Objective To investigate the rational use of antibiotics in surgical operation during perioperative period. Methods Through clinical clinical pharmacists accumulated experience in the clinical process, summarizes the rational use of antibiotics during perioperative clean-up surgery and recommendations. Results There was an irrational use of perioperative antibiotics, mainly in the absence of evidence-based medication, inappropriate timing of medication, and long postoperative medication duration. Conclusions Antibiotics play a significant role in preventing postoperative infection, increasing surgical safety and improving cure rate. However, if not properly used, it will also cause adverse reactions. Clinical pharmacists should better assist clinicians rational use of perioperative antibiotics.