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目的:探讨扩张型心肌病(DCM)患者外周血中Treg/Th17的水平及意义。方法:采用流式细胞术和ELISA法检测30例DCM患者和30例健康对照组Treg/Th17的水平。结果:DCM患者较正常组,外周血Treg细胞比例明显降低,而Th17细胞比例明显增高。Treg细胞相关细胞因子(TGF-β1和IL-10)的血浆水平明显降低,而Th17相关细胞因子(IL-17,IL-6,IL-23)水平明显增加。结论:DCM患者体内Treg细胞与Th17细胞平衡发生负向偏倚。
Objective: To investigate the level and significance of Treg / Th17 in peripheral blood of patients with dilated cardiomyopathy (DCM). Methods: Treg / Th17 levels in 30 patients with DCM and 30 healthy controls were detected by flow cytometry and ELISA. Results: Compared with the normal group, the proportion of Treg cells in peripheral blood was significantly decreased and the proportion of Th17 cells was significantly increased in patients with DCM. The plasma levels of Treg-related cytokines (TGF-β1 and IL-10) were significantly decreased while the levels of Th17-related cytokines (IL-17, IL-6 and IL-23) were significantly increased. Conclusion: The balance of Treg cells and Th17 cells in patients with DCM is negatively biased.