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小儿慢性肾功能不全患者在成功地接受肾移植之后身体生长加快,但是仍有一些患儿不能正常生长。为此,已有试验用重组的生长激素(rGH)进行替代治疗。作者报告2例可能是该疗法引起移植肾发生急性排斥反应的病例。例1。男,8岁,因肾发育异常于1985年1月行尸体肾移植。术后经过平稳,并维持每日给予环孢素240mg,隔日给强的松龙10mg。因生长迟缓于1988年12月开始用人类生长激素(hGH)治疗。当时血清肌酐在50～115μmol/L之间,胰岛素清除率为56ml/min/1.73m~2。5个月后肌酐突然升高至214μmol/L。肾活检显示弥漫性水肿以及间质炎性细胞
In children with chronic renal insufficiency, the body grows faster after a successful kidney transplant, but some children still do not grow normally. For this reason, there have been trials using recombinant growth hormone (rGH) for replacement therapy. The authors report 2 cases may be caused by the therapy of acute renal rejection rejection cases. example 1. Male, 8 years old, renal transplant due to renal dysplasia in January 1985. Postoperative smooth, and to maintain cyclosporine daily 240mg, every other day to prednisolone 10mg. Due to growth retardation began in December 1988 with human growth hormone (hGH) treatment. At that time serum creatinine was between 50 ~ 115μmol / L, insulin clearance 56ml / min / 1.73m ~ 2.5 months after the creatinine suddenly increased to 214μmol / L. Renal biopsy showed diffuse edema and mesenchymal inflammatory cells