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目的探讨计算机X线断层扫描(CT)及血清肿瘤标记物联合在肝癌诊断中的作用。方法回顾分析本院100例原发性肝癌的病历资料,所有患者根据临床表现,经影像、肿瘤标记物及各项实验室指标检查确诊,部分患者经手术后病理证实为肝癌。患者均行化学发光法检测血清甲胎蛋白(AFP)、癌相关抗原(CA)125、CA199、癌胚抗原(CEA)水平及CT扫描。结果肿瘤标记物血清AFP、CA199、CA125、CEA灵敏度及特异度随结节增大而升高,提高最明显为4项肿瘤标记物联合检测,将4项肿瘤标记物与CT扫描结果联合,灵敏度、特异度可提高到96.4%、90.0%。结论 CT扫描和肿瘤标记物合理的综合利用,可提高对肝癌高危人群的筛查及原发性肝癌的诊断。
Objective To explore the role of computed tomography (CT) and serum tumor markers in the diagnosis of liver cancer. Methods A retrospective analysis of 100 cases of primary liver cancer records, all patients based on clinical manifestations, imaging, tumor markers and various laboratory tests confirmed the diagnosis, some patients confirmed by pathology after liver cancer. The patients underwent chemiluminescence to detect serum AFP, CA125125, CA199, CEA and CT scan. Results The sensitivity and specificity of tumor markers AFP, CA199, CA125 and CEA increased with the increase of nodules, and the most obvious was the combination of 4 tumor markers. The combination of 4 tumor markers and CT scan results showed that the sensitivity , The specificity can be increased to 96.4%, 90.0%. Conclusion The reasonable utilization of CT scan and tumor markers can improve the screening of high-risk population of liver cancer and the diagnosis of primary liver cancer.