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目的 观察小剂量卡维地洛治疗重度充血性心力衰竭 (CHF)的临床耐受性和安全性。方法 2 8例重度CHF患者在标准治疗基础上 (利尿剂、血管紧张素转换酶抑制剂 (ACEI)和洋地黄类制剂等 )加用卡维地洛 ,起始剂量 3.12 5mg ,2 /d ,2周后增至 6 .2 5mg ,2 /d ,维持 3个月 ,治疗前后分别对患者心功能 (NYHA分级法 )、血压、心率、及生化指标进行检测 ,以评价小剂量卡维地洛治疗重度CHF的耐受性、安全性及疗效。结果 应用小剂量卡维地洛治疗 3个月后患者心功能较治疗前改善 ,12例心功能由Ⅲ、Ⅳ级改善为Ⅱ级 ,心率、左心室舒张末期压下降 ,不良反应少 ,对肝肾功能、血糖、血脂、血常规均无影响 ,耐受性好。结论 小剂量卡维地洛治疗重症CHF短期疗效、耐受性及安全性良好
Objective To observe the clinical tolerability and safety of low-dose carvedilol in the treatment of severe congestive heart failure (CHF). Method 2 Eight patients with severe CHF were given carvedilol on the basis of standard treatment (diuretic, ACE inhibitors and digitalis preparations) with an initial dose of 3.12 5mg, 2 / d, 2 Week to 6.25mg, 2 / d for 3 months, respectively, before and after treatment of patients with cardiac function (NYHA classification), blood pressure, heart rate, and biochemical parameters were tested to evaluate the low-dose carvedilol treatment of severe CHF Tolerance, safety and efficacy. Results After 3 months treatment with low-dose carvedilol, heart function improved compared with before treatment. Heart function of 12 patients improved from grade Ⅲ and Ⅳ to grade Ⅱ. Heart rate and left ventricular end-diastolic pressure decreased with fewer adverse reactions. Renal function, blood glucose, blood lipids, blood no effect, good tolerance. Conclusion Low-dose carvedilol in short-term treatment of severe CHF, tolerance and safety are good