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目的:探讨依那普利对老年无症状性心力衰竭(silent heart tailur,SHF)的心功能改善作用。方法:未经治疗的SHF老年患者91例,随机分为治疗组46例(口服依那普利)及对照组45例(服用安慰剂),治疗16个月,观察两组患者治疗前后心功能(NYHA)分级评估情况和超声心动图心功能测量结果。结果:治疗组46例(100%)治疗后仍然维持心功能Ⅰ级,对照组45例(80%)维持心功能Ⅰ级(P<0.05)。治疗组左心室射血分数LVEF治疗后提高(P<0.05),而对照组下降(P<0.05),两组比较有显著性差异(P<0.05)。左心室收缩末期容积LVESV和左心室舒张末期容积LVEDV,治疗组治疗后明显下降(P<0.05),而对照组治疗后较治疗前上升(P>0.05),两组比较有显著性差异(P<0.05)。结论:依那普利早期干预SHF,可显著改善心功能,延缓老年患者心衰进展,降低住院率。
Objective: To investigate the effect of enalapril on heart function of senile silent heart tail (SHF). Methods: 91 untreated SHF elderly patients were randomly divided into treatment group 46 cases (oral enalapril) and control group 45 cases (taking placebo) for 16 months, the two groups were observed before and after treatment of cardiac function (NYHA) grading assessment and echocardiographic cardiac function measurement. Results: 46 cases (100%) in the treatment group still maintained the first grade of cardiac function, and 45 cases (80%) in the control group maintained the first grade of cardiac function (P <0.05). The left ventricular ejection fraction LVEF increased (P <0.05) in treatment group and decreased in control group (P <0.05). There was significant difference between the two groups (P <0.05). Left ventricular end-systolic volume LVESV and left ventricular end-diastolic volume LVEDV were significantly decreased in treatment group (P <0.05), while those in control group were significantly higher than those before treatment (P> 0.05). There was significant difference between the two groups <0.05). Conclusion: Enalapril early intervention SHF can significantly improve cardiac function, delay the progression of heart failure in elderly patients and reduce the hospitalization rate.