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目的 :研究中华肾宁片对急性肾衰大鼠肾功能的影响。方法 :SD大鼠 5 0只随机分成 5组 :正常组 (生理盐水 1.5ml/只 ,ig) ;模型组 (5 0 %甘油肌注 ) ;地塞米松治疗组 (ARF大鼠 ,0 .1mg/kg ,ig) ;中华肾宁片治疗组 (ARF大鼠 ,75 0mg/kg和 2 2 5 0mg/kg ,ig)。结果 :中华肾宁片可使ARF大鼠血清尿素氮 ,肌酐 ,K+ ,Na+ 降低 ,尿量增加 (P <0 .0 5 ,0 .0 0 1)。结论 :中华肾宁片对急性肾衰有治疗作用。
Objective: To study the effect of Zhongshenning tablet on renal function in rats with acute renal failure. METHODS: Fifty-five SD rats were randomly divided into 5 groups: normal group (normal saline 1.5 ml/kg, ig); model group (50% glycerol intramuscular injection); dexamethasone treatment group (ARF rats, 0.1 mg /kg ,ig); Zhonghua Shenning Tablets treatment group (ARF rats, 750 mg/kg and 2250 mg/kg, ig). RESULTS: Zhongshenning Tablet could reduce serum urea nitrogen, creatinine, K+, Na+ and increase urine volume in ARF rats (P < 0.05, 0.01). Conclusion : Zhonghua Shenning Tablet has therapeutic effect on acute renal failure.