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目的探讨不同来源精子对卵胞浆内单精子注射助孕结局的影响。方法回顾分析我中心2008年1月至2012年6月1129个ICSI治疗周期,射出A组858例,附睾穿刺B组229例,睾丸穿刺C组42例,比较3组的临床结局。结果 A组年龄较B、C组大,内膜厚度薄;C组获卵数及ICSI卵数较A、B组多;B组优质胚胎率高于A组,种植率及活产率高于A、C两组(P<0.05)。通过多元逻辑斯蒂回归模型分析精子来源与活产率的相关性,校正混杂因素后,A组相对于B组的OR值为0.559(95%CI 0.416-0.752),C组相对于B组的OR值为0.513(95%CI 0.264-0.998)。结论附睾穿刺来源精子行ICSI可获得较好的临床结局。
Objective To investigate the effect of sperm from different sources on the pregnancy outcome of intracytoplasmic sperm injection. Methods A total of 1129 ICSI cycles from January 2008 to June 2012 in our center were retrospectively analyzed. There were 858 cases in group A, 229 cases in epididymal puncture group B and 42 cases in group C in testis puncture. The clinical outcomes of the three groups were compared. Results The age of group A was larger than that of group B and C, and the thickness of intima was thin. The number of oocytes and the number of ICSI eggs in group C were more than those in group A and B. The rate of high-quality embryos in group B was higher than that in group A, A, C two groups (P <0.05). The multivariate logistic regression model was used to analyze the correlation between sperm source and live birth rate. After adjusting for confounding factors, the OR of group A relative to group B was 0.559 (95% CI 0.416-0.752), while that of group C relative to group B The OR value was 0.513 (95% CI 0.264-0.998). Conclusion Epidural sperm source ICSI suture can get better clinical outcome.