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目的初步探讨人血管内皮抑制肽在小鼠/裸鼠移植瘤术后残瘤模型中的抗癌药效学作用。方法建立S180肉瘤昆明小鼠手术后残瘤和人结肠癌Lovo裸鼠手术后残瘤模型,评价人血管内皮抑制肽对小鼠手术后残瘤的抑制效应,选择恩度(重组人血管内皮抑素)作为阳性对照药。结果人血管内皮抑制肽给药组对S180肉瘤昆明小鼠手术后残瘤生长产生较强的抑制作用,按照肿瘤体积得出的抑制率范围为16.9%～43.9%,按照瘤重得出的抑制率范围为21.2%～45.5%;人血管内皮抑制肽给药组对人结肠癌Lovo裸鼠手术后残瘤生长产生较强的抑制作用,按照肿瘤体积得出的抑制率范围为42.0%～70.3%,按照瘤重得出的抑制率范围为45.5%～73.8%。结论人血管内皮抑制肽对小鼠/裸鼠手术后残瘤的生长具有较强的抑制作用,为人血管内皮抑制肽开发和临床应用奠定了基础。
Objective To investigate the anti-cancer pharmacodynamic effect of human vascular endothelial inhibitor on the model of post-operative tumor in mice / nude mice. Methods The residual tumor model of the S180 sarcoma Kunming mouse after operation and the human colon carcinoma Lovo nude mice were established to evaluate the inhibitory effect of human vascular endothelial inhibitor on the residual tumor after the operation in mice. Su) as a positive control drug. Results The human vascular endothelial inhibitor peptide-treated group had a strong inhibitory effect on the growth of residual tumor after the operation of S180 sarcoma Kunming mice. The inhibition rates obtained by tumor volume ranged from 16.9% to 43.9% The rate ranged from 21.2% to 45.5%. The human vascular endothelial inhibitory peptide-administered group had a strong inhibitory effect on the growth of the residual tumor of human colon cancer Lovo nude mice after operation, and the inhibition rate in the tumor volume ranged from 42.0% to 70.3 %, According to tumor weight derived inhibition ranged from 45.5% to 73.8%. Conclusion Human vascular endothelial inhibitory peptide has a strong inhibitory effect on the growth of post-operative residual tumor in mice / nude mice, which lays the foundation for the development and clinical application of human vascular endothelial inhibitor.