给３０名健康成人、３０名儿童、１５名血液病患儿、１５名新生儿住院患者服用自行配制的含双歧杆菌的活菌饮料，分析服用前后肠道菌群及ＳＩｇＡ含量，结果提示服用外源性双歧杆菌后，健康成人、儿童、新生儿住院患者肠道内类杆菌数量减少，成人粪便中分泌ＳＩｇＡ的水平上升，儿童肠道内双歧杆菌数量增加，血液病患儿因口服抗生素，肠道菌群及ＳＩｇＡ变化不显著。 Thirty healthy adults, 30 children, 15 children with hematological diseases and 15 newborn inpatients were enrolled in this study. Bifidobacterium-containing live-bacteria beverages were prepared and their intestinal flora and SIgA levels were analyzed before and after taking the drug. After exogenous Bifidobacterium, healthy adults, children, neonatal inpatient intestinal Bacterial count decreased, adult excretion of SIgA levels increased, the number of children with intestinal bifidobacteria increased, blood disease due to oral antibiotics, Intestinal flora and SIgA changes were not significant.