近年来,证明了铂化合物具有显著抗癌活性,顺氯氨铂(DDP)已应用于临床,对睾丸肿瘤、肉瘤类等有较佳的疗效。为了寻找新的有效低毒药物,由南京大学配位化学研究所合成铂络合物新药,中山医学院肿瘤研究所进行动物实验研究。第一批4种新合成四价铂化合物具有显著抗瘤作用已经报告。为了比较各药抗瘤活性及毒性的差异,对各药进行 In recent years, it has been demonstrated that platinum compounds have significant anti-cancer activity, and cisplatin (DDP) has been used clinically and has a better therapeutic effect on testicular tumors and sarcomas. In order to find new effective and low-toxic drugs, a new platinum complex drug was synthesized by the Institute of Coordination Chemistry, Nanjing University, and an animal experimental study was conducted at the Cancer Institute of Zhongshan Medical College. The first four new synthetic tetravalent platinum compounds have been shown to have significant anti-tumor effects. In order to compare the difference in the antitumor activity and toxicity of each drug, each drug was tested.