论文部分内容阅读
目的了解原发性肾病综合征(NS)并发医院获得性肺炎(HAP)的发病率、病原菌分布及对抗生素的敏感性。方法对2004年6月至2006年12月我院收治的43例原发性肾病综合征合并医院获得性肺炎患者进行回顾性分析。结果共分离出细菌51株,其中革兰阴性菌占72.5%,以肺炎克雷伯杆菌、铜绿假单胞菌、不动杆菌、大肠埃希菌最常见;革兰阳性菌占21.6%,主要是金黄色葡萄球菌、表皮葡萄球菌;真菌占3.9%;两种细菌感染的占18.6%,其中真菌均与革兰阴性菌混合感染,占混合感染的25%。致病菌对常用抗生素都不同程度地产生了耐药性,对青霉素、氨苄西林的耐药率最高,对亚胺培南、β-内酰胺酶抑制剂复合剂的耐药率较低,未发现万古霉素耐药革兰阳性球菌。结论革兰阴性杆菌为主要致病菌,其次为革兰阳性菌,多为条件致病菌,且细菌耐药性严重。
Objective To understand the incidence of primary nephrotic syndrome (NS) associated with hospital acquired pneumonia (HAP), the distribution of pathogens and the sensitivity to antibiotics. Methods A retrospective analysis was performed on 43 patients with primary nephrotic syndrome admitted to our hospital from June 2004 to December 2006 with hospital acquired pneumonia. Results A total of 51 strains of bacteria were isolated, of which Gram-negative bacteria accounted for 72.5%, with Klebsiella pneumoniae, Pseudomonas aeruginosa, Acinetobacter, Escherichia coli most common; Gram-positive bacteria accounted for 21.6%, mainly Is Staphylococcus aureus, Staphylococcus epidermidis; fungi accounted for 3.9%; two kinds of bacterial infections accounted for 18.6%, of which fungi were mixed with gram-negative bacteria infection, accounting for 25% of mixed infections. Pathogenic bacteria commonly used antibiotics have different levels of resistance, resistance to penicillin, ampicillin, the highest rate of resistance to imipenem, β-lactamase inhibitor complex, not Vancomycin-resistant Gram-positive cocci was found. Conclusions Gram-negative bacilli are the main pathogens, followed by Gram-positive bacteria, mostly opportunistic pathogens, and bacterial resistance is serious.