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目的为了加强二级预防,减少异常胎儿出生,提高出生人口素质,寻找一种有效的检测方法发现可能先天异常胎儿及不良妊娠结局的风险,筛查可疑者采取必要的产前诊断措施。方法采用全自动时间荧光分辨检测仪测定孕妇血清中AFP、Free-βHCG、uE3的值,结合其他相关因素,通过lifecycle风险评估软件估算三种先天异常的风险;预产年龄≥35周岁、多胎及曾分娩过先天性严重缺陷胎儿的孕妇直接归类于高风险人群。结果与结论孕中期产前筛查是一种可以预测异常胎儿和不良妊娠结局的有效指标。
Objective To strengthen secondary prevention, reduce abnormal fetal birth, improve the quality of birth population, find an effective detection method to detect possible fetal abnormalities and adverse pregnancy outcomes, and screen suspects to take the necessary prenatal diagnostic measures. Methods The serum levels of AFP, Free-βHCG and uE3 in pregnant women were measured by automatic time fluorescence detector, and the risks of three congenital anomalies were estimated by lifecycle risk assessment software. The predictive value of AFP, Free- Pregnant women who have given birth to a fetus with severe congenital defects are classified directly into high-risk groups. RESULTS AND CONCLUSIONS The second trimester prenatal screening is a useful indicator of unexpected fetuses and adverse pregnancy outcomes.