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研究了正常和氯丙烯染毒(剂量为100mg/kg)后大鼠脊髓神经细胞胆碱酯酶(CHE)的活力变化。正常对照组脊髓前角和中央管两侧神经细胞胞浆内CHE染成靛蓝色;染毒后,CHE活力下降,即在少数神经细胞内显现少量的淡靛蓝色颗粒。CHE活力降低以腰髓最重。毛细血管周边CHE活力与对照组相似。说明氯丙烯致神经细胞CHE活力下降是由于细胞体受影响,并非直接抑制了CHE的活力。对细胞体的影响可能是因其直接作用于周围神经纤维,引起微管和神经微丝变性,阻断了轴浆运输,使轴突破坏或阻断的信息传到细胞体或从神经终末端到细胞体的信息反馈中断,影响了CHE的合成。
The changes of activity of cholinesterase (CHE) in rat spinal cord neurons after normal and allyl chloride exposure (100 mg / kg) were studied. In normal control group, the CHE in the cytoplasm of neurons in the spinal cord anterior horn and central tube were dyed to indigo. CHE activity decreased after exposure to a small amount of light indigo blue granules in a few neurons. CHE vitality reduced to the lumbar spinal cord heaviest. Capillary Peripheral CHE activity similar to the control group. These results indicate that the decrease of CHE activity induced by allyl chloride is due to the influence of cell body, but not the direct inhibition of CHE activity. The effect on the cell body may be due to its direct effect on the peripheral nerve fibers, causing degeneration of microtubules and neurofilaments, blocking axoplasmic transport, axonal destruction or blockage of the message to the cell body or from the nerve terminal Information feedback to the cell body is interrupted, affecting the synthesis of CHE.