论文部分内容阅读
目的：探索谷氨酸（Ｇｌｕ）和促肾上腺皮质激素（ＡＣＴＨ）在急性脑缺血及其应激反应中的病理生理学意义。方法：应用高效液相色谱分析等方法检测了２８例首次发病的急性脑梗死（ＡＣＩ）患者发病７２小时内的血浆和脑脊液（ＣＳＦ）中Ｇｌｕ及ＡＣＴＨ浓度变化，并与同期检测的神经功能缺失程度（ＣＳＳ积分）、ＣＴ测量脑梗死体积（ＣＩＶ）进行相关分析；并另设同期住院的非心、脑血管病患者１０例为对照组。结果：２８例ＡＣＩ患者的血浆Ｇｌｕ〔（１６９．２９±３２．５３）ｍｍｏｌ／Ｌ〕、ＡＣＴＨ〔（１４．８０±６．０８）ｐｍｏｌ／Ｌ〕和ＣＳＦ中Ｇｌｕ〔（１０．４８±３．２９）ｍｍｏｌ／Ｌ〕、ＡＣＴＨ〔（３．８８±１．２９）ｐｍｏｌ／Ｌ〕浓度均显著高于对照组〔血浆Ｇｌｕ（１２９．２０±２８．１５）ｍｍｏｌ／Ｌ，ＡＣＴＨ（８．５８±０．８１）ｐｍｏｌ／Ｌ；ＣＳＦ中Ｇｌｕ（３．０９±１．４８）ｍｍｏｌ／Ｌ，ＡＣＴＨ（１．９７±０．８１）ｐｍｏｌ／Ｌ，Ｐ＜０．００１～０．０５〕；其血浆和ＣＳＦ中Ｇｌｕ浓度分别与血浆和ＣＳＦ中ＡＣＴＨ浓度呈非常显著或显著正相关（ｒ分别为０．４９３和０．４０２，Ｐ＜０．０１和Ｐ＜０．０５）。结论：Ｇｌｕ参与了ＡＣＩ?
Objective: To explore the pathophysiological significance of glutamate (Glu) and adrenocorticotropic hormone (ACTH) in acute cerebral ischemia and its stress response. Methods: The concentrations of Glu and ACTH in plasma and cerebrospinal fluid (CSF) of 28 patients with first-episode acute cerebral infarction (ACI) were detected by high performance liquid chromatography (HPLC) (CSS score), CT measurement of cerebral infarction volume (CIV) were analyzed. Another 10 patients with non-cardiac and cerebrovascular diseases hospitalized in the same period were selected as the control group. Results: The plasma levels of Glu (169.29 ± 32.53) mmol / L, ACTH 〔(14.80 ± 6.08) pmol / L〕 and Glu 〔(10.48 ± 3) .29 mmol / L] and ACTH 〔(3.88 ± 1.29) pmol / L〕 were significantly higher than those in the control group 〔plasma Glu (129.20 ± 28.15) mmol / L, ACTH 58 ± 0.81) pmol / L; Glu (3.09 ± 1.48) mmol / L and ACTH (1.97 ± 0.81) pmol / L in CSF, P <0.001 ~ 0.05] . The concentrations of Glu in plasma and CSF were significantly or significantly positively correlated with the concentrations of ACTH in plasma and CSF, respectively (r = 0.493 and 0.402, P <0.01 and P <0.05, respectively). Conclusion: Glu participates in ACI?