１９９３年，Ｄａｈｌｂｃｋ等在家族性易栓症患者中发现抗活化的蛋白Ｃ现象（ａｃｔｉｖａｔｅｄｐｒｏｔｅｉｎＣｒｅｓｉｓｔａｎｃｅ，ＡＰＣＲ）。此后，在欧美国家静脉血栓性疾病患者中发现凝血因子Ⅴ（ＦⅤ）基因第１６９１位的核苷酸Ｇ→Ａ点突变（即ＦⅤＬｅｉｄｅ In 1993, Dahlbck et al found that activated protein C (APCR) was found in familial patients with thrombophilia. Since then, in the United States and Europe, patients with venous thrombosis found in coagulation factor Ⅴ (F Ⅴ) gene at position 1691 nucleotide G → A point mutation (ie F Ⅴ Leide