论文部分内容阅读
目的探讨持续正压通气联合盐酸氨溴索治疗新生儿呼吸窘迫综合征(NRDS)的临床效果。方法选取广州中医药大学第一附属医院新生儿科2011年1月—2014年2月收治的NRDS患儿140例,采用随机数字表法分为对照组和试验组,每组70例。对照组患儿采用吸氧与盐酸氨溴索联用治疗;试验组患儿则采用持续正压通气联合盐酸氨溴索治疗;比较两组患儿临床疗效、病死率,治疗前后血氧饱和度、心率及呼吸频率。结果对照组和试验组患儿治疗总有效率分别为67.1%、91.4%;两组差异有统计学意义(P<0.05)。对照组和试验组患儿病死率分别为18.6%、5.7%;两组差异有统计学意义(P<0.05)。两组患儿治疗后血氧饱和度高于治疗前,心率及呼吸频率低于治疗前(P<0.05);治疗后试验组患儿血氧饱和度高于对照组,心率及呼吸频率低于对照组,差异有统计学意义(P<0.05)。结论持续正压通气联合盐酸氨溴索治疗NRDS可有效减轻患者临床症状、体征,改善生命体征,并降低病死率。
Objective To investigate the clinical effect of continuous positive pressure ventilation combined with ambroxol hydrochloride in the treatment of neonatal respiratory distress syndrome (NRDS). Methods 140 cases of NRDS children admitted to Department of Neonatology, the First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine between January 2011 and February 2014 were randomly divided into control group and experimental group with 70 cases in each group. Children in the control group were treated with inhaled oxygen and ambroxol hydrochloride. Patients in the experimental group were treated with continuous positive pressure ventilation combined with ambroxol hydrochloride. The clinical efficacy, mortality, oxygen saturation before and after treatment , Heart rate and respiratory rate. Results The total effective rate of treatment in the control group and experimental group was 67.1% and 91.4% respectively. The difference between the two groups was statistically significant (P <0.05). The case fatality rates of the control group and the experimental group were 18.6% and 5.7% respectively; there was a significant difference between the two groups (P <0.05). The oxygen saturation of the two groups was higher than that before treatment, and the heart rate and respiratory rate were lower than before treatment (P <0.05). After treatment, the oxygen saturation of children in the experimental group was higher than that of the control group, heart rate and respiratory rate were lower than Control group, the difference was statistically significant (P <0.05). Conclusion Continuous positive pressure ventilation combined with ambroxol hydrochloride in the treatment of NRDS can effectively reduce the clinical symptoms, signs, improve vital signs and reduce the mortality.