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本文对12例长期服用慢心律(mexiletine)者进行研究,旨在讨论长期服用后的副作用。方法 12例室性心律失常患者,服慢心律治疗时间4～96(平均47.8)个月。开始剂量200mg,每日3次。在服药最初18个月内,测血浆浓度记录其副作用。18个月后的随访包括不定期测定血红蛋白、血沉、尿糖和尿蛋白等。结果服药后头18个月未发现有关的实验室异常及对肝、肾或心血管系统的副作用,也未发现抗核因子滴度升高。副作用有:手指快速震颤4例、眩晕2
In this paper, 12 long-term taking mexiletine were studied in order to discuss the long-term side effects. Methods Twelve patients with ventricular arrhythmia received slow bradycardia for 4 to 96 (mean, 47.8) months. Start dose 200mg, 3 times a day. During the first 18 months of medication, plasma concentrations were recorded for side effects. Follow-up after 18 months includes irregular determination of hemoglobin, erythrocyte sedimentation rate, urine glucose and urine protein. Results No relevant laboratory abnormalities and side effects on the liver, kidney or cardiovascular system were found in the first 18 months after taking the drug. No antinuclear titers were observed. Side effects are: finger tremor in 4 cases, dizziness 2