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以抗细胞角质蛋白－１８（ＣＫ－１８）单克隆抗体为标记抗体，采用免疫细胞化学染色方法研究了６４例泌尿系统肿瘤在骨髓中的微转移，发现２８．１％的病人有骨髓微小转移。此方法可以将癌细胞染成红色，显微镜下很容易与正常骨髓细胞相区别。我们认为此方法敏感、准确、实用，同一种方法可用于不同癌症患者的检查。
Anti-cytokeratin-18 (CK-18) monoclonal antibody was used as a labeling antibody. Micrometastases in 64 patients with urinary system tumors were studied by immunocytochemical staining. 28.1% of patients had micrometastases in bone marrow. . This method can stain cancer cells red and can be easily differentiated from normal bone marrow cells under a microscope. We believe this method is sensitive, accurate, and practical. The same method can be used for the examination of patients with different cancers.