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探讨了鸡卵白蛋白(OVA)致敏的BALB/c小鼠经过OVA雾化吸入刺激后,其支气管肺泡灌洗液(BALF)中EOS数量的变化。结果发现,以OVA10μg腹腔注射3次,间隔2周,然后给予5%OVA雾化吸入20min,每天1次,共6d,BALF中EOS数可达(9.67±0.80)×108/L.认为这是一种较理想的气道过敏性炎症模型。
To investigate the changes of EOS in bronchoalveolar lavage fluid (BALF) of BALB / c mice sensitized with OVA after OVA inhalation. The results showed that the number of EOS in BALF was (9.67 ± 0.80) × 108 / L after intraperitoneal injection of OVA10μg three times at intervals of 2 weeks and then inhaled 5% OVA for 20min, once daily for 6 days . Think this is a more ideal airway allergic inflammation model.