论文部分内容阅读
自Crowther和Smith(1964)合成心得安,并首次成功地用于临床以来,β-肾上腺素能受体阻断剂(以下简称β阻断剂)经过多年发展,除少数已淘汰、停产或尚未正式生产外,国内目前用于临床的有十余种,而且大多系用于防治心血管疾病.近年来,国内外根据其作用原理和药代动力学特点,在对神经精神性疾病的防治方面进行了探索,并取得一定的疗效.本文主要介绍国外对这类药物在该领域中的应用情况,并就其疗效和存在问题,加以评述.
Since the combination of propranolol by Crowther and Smith (1964) and for the first time successfully used in the clinic, beta-adrenergic receptor blockers (hereinafter referred to as beta blockers) have evolved over the years, with the exception of a few that have been phased out, discontinued or have not Formal production, the domestic currently used in clinical there are more than 10 species, and mostly used for the prevention and treatment of cardiovascular disease.In recent years, both at home and abroad according to their role and pharmacokinetics, in the prevention and treatment of neuropsychiatric diseases Has been explored and achieved some curative effect.This paper mainly introduces the foreign application of these drugs in this field, and reviews its curative effect and existing problems.