目的　评价在结直肠癌肝转移的患者中应用药物输注装置进行化疗的治疗意义。方法　应用药物输注装置治疗结直肠癌肝转移患者 36例 ,均于手术切除原发肿瘤的同时经肝动脉插入导管 ,导管的另一端经腹壁至皮下与药泵相连。分别于术中及术后 3～ 4周进行化疗 (FM或FAM方案 )。结果　所有患者经治疗后均见转移灶有明显缩小 ,其中生存不足 12月者 3例 ,12～ 2 4月者 5例 ,2 4～ 36月 6例 ,超过 36月者 8例 ;7例经药物输注装置局部化疗后转移灶消失 ,9例转移灶减小、孤立 ,行再次手术切除。结论　药物输注装置对于伴有肝转移的结直肠癌患者是一种有效的辅助治疗手段 ,利用药物输注装置进行局部化疗时需要掌握指征并应避免并发症 Objective To evaluate the therapeutic effect of chemotherapeutic drug delivery in patients with liver metastases from colorectal cancer. Methods 36 cases of patients with liver metastasis of colorectal cancer were treated with drug infusion device. All of them were inserted into the catheter through the hepatic artery while the primary tumor was resected. The other end of the catheter was connected to the drug pump through the abdominal wall and subcutaneously. Chemotherapy (FM or FAM regimen) was performed intraoperatively and 3 to 4 weeks after surgery. Results All patients showed significantly reduced metastases after treatment. Among them, 3 cases were underdeveloped in 12 months, 5 cases were in 12 ~ 24 months, 6 cases were in 24 ~ 36 months and 8 cases were beyond 36 months. Metastatic devices disappeared after local chemotherapy in the drug infusion device, and 9 cases were reduced, isolated and resected. Conclusion The drug infusion device is an effective adjunctive therapy for patients with colorectal cancer with liver metastasis. Indications and complications should be taken when using local chemotherapy with drug infusion device