A general and convenient practical approach for the synthesis of polyhydroquinoline derivatives has been achieved via one-pot four-component Hantzsch condensation of aromatic aldehydes,dimedone,ethyl acetoacetate and ammonium acetate in the presence of a catalytic amount of cerium(Ⅳ)ammonium nitrate (CAN),in ethanol solvent at ambient temperature.Simple work-up, mild reaction conditions,inexpensive and non-toxic catalyst,and excellent product yields are the advantageous features of this method. A general and convenient practical approach for the synthesis of polyhydroquinoline derivatives has been achieved via one-pot four-component Hantzsch condensation of aromatic aldehydes, dimedone, ethyl acetoacetate and ammonium acetate in the presence of a catalytic amount of cerium (IV) ammonium nitrate ( CAN), in ethanol solvent at ambient temperature. Simple work-up, mild reaction conditions, inexpensive and non-toxic catalyst, and excellent product yields are the advantageous features of this method.