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目的通过检测β-连环素(β-cat)在子宫内膜癌中的表达,探讨其临床意义。方法采用免疫组化SABC法检测31例子宫内膜癌和10例正常子宫内膜组织β-cat的表达。结果31例子宫内膜癌74%为浆/核聚集表达,明显大于正常子宫内膜(P<0.05)。其中Ⅰ期为84%,明显高于Ⅱ、Ⅲ期(P<0.05);内膜样腺癌为88%,明显高于非内膜样腺癌(P<0.01),且60%分化良好,P<0.05。不同肌层浸润深度间比较差异无统计学意义,P>0.05。结论β-cat聚集可能与子宫内膜癌发生有关,尤其与早期、分化良好的内膜样腺癌的发生有关,与肌层浸润深度无关。
Objective To investigate the clinical significance of β-cat (β-cat) expression in endometrial carcinoma by detecting its expression. Methods Immunohistochemical SABC method was used to detect the expression of β-cat in 31 cases of endometrial carcinoma and 10 cases of normal endometrium. Results Thirty-four cases of endometrial carcinoma were plasma / nuclear aggregates, which was significantly larger than that of normal endometrium (P <0.05). (84%) in stage Ⅰ, which was significantly higher than that in stage Ⅱ and Ⅲ (P <0.05). The rate of endometrial adenocarcinoma was 88%, which was significantly higher than that in non-endometrioid adenocarcinoma (P <0.01) P <0.05. There was no significant difference in the depth of invasion between different muscle layers, P> 0.05. Conclusion β-cat aggregation may be related to the occurrence of endometrial cancer, especially with early, well-differentiated endometrioid adenocarcinoma, and has nothing to do with the depth of myometrial invasion.