6-氟萘啶酸曾在实验室中从6-硝基萘啶酸制得,但最后一步的置换反应收率低、波动大,不适于大规模合成。自从用Balz-schiemann反应制得各种氟化物后,便采取在合成开始就引入6-氟原子。这条路线提供了较早引入氟的方法,且以后的各步反应得率高,易于扩大生产。合成方法,取N-(5-氨基-6-甲基)-2-吡啶基)-乙酰胺(1)于48%HBF4溶液中制得四氟硼酸盐(2),(2)在甲苯中经热重排得N-(5- 6-Nalidixic acid has been prepared from 6-nitronaphthenic acid in the laboratory, but the last step of the replacement reaction yields low volatility and is not suitable for large-scale synthesis. Since various fluorides have been prepared by the Balz-schiemann reaction, a 6-fluorine atom is introduced at the beginning of the synthesis. This route provides an early introduction of fluorine, and the subsequent steps of the reaction rate is high, easy to expand production. Synthesis method, taking N- (5-amino-6-methyl) -2- pyridyl) - acetamide (1) in 48% HBF4 solution obtained tetrafluoroborate (2), (2) in toluene In thermal rearrangement N- (5-