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Walshe 和 Dixon 提出对青霉胺维持疗法的非顺应性是 Wilson 病的危险之一。他们的见解夸大了青霉胺的潜在毒性。Emery 和 Mackay 则担心医生们过高估计青霉胺危险的倾向可能促进了这种非顺应性。他们描述那些医生是如何勉强地使用青霉胺,致使他们的病人停用所有驱铜疗法,随之而来是神经症
Walshe and Dixon suggest that non-compliance with penicillamine maintenance therapy is one of the risks of Wilson’s disease. Their opinion exaggerates the potential toxicity of penicillamine. Emery and Mackay worry that physicians’ tendency to overestimate the risk of penicillamine may have contributed to this non-compliance. They described how reluctantly those doctors used penicillamine, causing their patients to disable all copper-drive therapies, followed by neurosis