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本文利用缩窄大鼠腹主动脉的方法制备高血压模型，观察了正常大鼠、未服和口服Ｌ－精氨酸两周的腹主动脉狭窄的大鼠的血压、心肌肥厚及血管舒张功能的改变，旨在了解Ｌ－精氨酸对腹主动脉缩窄性高血压大鼠的作用。研究发现腹主动脉狭窄后大鼠发生了严重的高血压及心肌肥厚。未服Ｌ－精氨酸的大鼠心肌肥厚，且血管环对１０－８～１０－５ｍｏｌ／Ｌ乙酰胆碱诱导的舒张反应明显减低；而Ｌ－精氨酸口服治疗两周能减轻其心肌肥厚，并部分改善乙酰胆碱诱导的血管舒张功能，但两组大鼠腹主动脉缩窄后的血压均升高，两者相比较差别无统计学意义（Ｐ＞０．０５）。结果提示：Ｌ－精氨酸（１０－５～１０－３ｍｏｌ／Ｌ）有直接舒张该大鼠血管环的作用，且呈剂量依赖关系，长期口服Ｌ－精氨酸可减轻腹主动脉缩窄性大鼠的心肌肥厚，改善其血管的舒张功能，而其血压的变化与上述作用无关。
In this paper, the rat abdominal aorta narrowing the preparation of the model of hypertension, normal rats, unobserved and oral L-arginine two weeks of abdominal aortic stenosis rat blood pressure, cardiac hypertrophy and vasodilation To understand the role of L-arginine in abdominal aorta-induced hypertensive rats. Study found that abdominal aortic stenosis occurred in rats with severe hypertension and myocardial hypertrophy. L-arginine in rats without myocardial hypertrophy, and vascular ring on the 10-8 ~ 10-5mol / L acetylcholine induced diastolic response was significantly reduced; and L-arginine oral administration of two weeks to reduce its cardiac hypertrophy, And partly improve the function of acetylcholine-induced vasodilatation. However, the blood pressure of the abdominal aorta of both groups increased after the narrowing of both groups. There was no significant difference between the two groups (P> 0.05). The results suggest that L-arginine (10-5 ~ 10-3mol / L) can directly relax the vascular rings in a dose-dependent manner. Long-term oral administration of L-arginine can reduce abdominal aortic constriction Myocardial hypertrophy in rats improves the vasodilatation of blood vessels, whereas changes in blood pressure have nothing to do with these effects.