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目的探讨尿毒症患者抗生素脑病的发病机制、临床特点、治疗方法及预后,提高临床医师对尿毒症患者抗生素脑病的认识。方法对17例尿毒症患者使用抗生素后出现神经精神症状及治疗进行回顾分析。结果抗生素脑病的神经精神症状表现多样,无神经系统定位体征,停药并行血液净化后症状消失。结论尿毒症患者使用抗生素,可引起一过性脑病,在用药时,应注意药物的选择,严密观察,出现神经精神症状,立即停药,加强血液净化治疗,预后良好。
Objective To investigate the pathogenesis, clinical features, treatment and prognosis of patients with uremia with antibiotic encephalopathy and to improve their understanding of antibiotic encephalopathy in patients with uremia. Methods The neuropsychiatric symptoms and treatment of 17 patients with uremia after antibiotics were retrospectively analyzed. Results There were many neuropsychiatric symptoms in antibiotic encephalopathy, no signs of nervous system localization and symptoms disappeared in parallel with blood purification. Conclusions The use of antibiotics in patients with uremia can cause transient encephalopathy. In the course of medication, attention should be paid to the choice of drugs, strict observation, neuropsychiatric symptoms, withdrawal immediately, enhancement of blood purification treatment, and good prognosis.