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目的 探讨一种针对胰腺间质结构的自身免疫性抗体在急性胰腺炎不同病程中的表达情况 ,并分析其可能的意义。方法 采用临床病例分析的方法 ,于发病后第 1、2、4、7天分别取静脉血 ,用间接免疫荧光法对血样中的抗胰腺间质抗体进行定性分析。并测定尿淀粉酶和观察临床体征的变化。结果 随着病程的进展 ,该抗体的阳性表达率逐渐增加 ,差异有显著性 (P <0 .0 5 ) ,其阳性表达率的增加与临床症状的好转 (r =0 .996)及生化指标的恢复呈正相关 (r =0 .95 1)。结论 在急性胰腺炎患者的恢复期血清中逐渐有增强的自身抗体表达 ,该抗体主要是针对胰腺的间质结构 ,且可能在胰腺炎的病程中起保护作用
Objective To investigate the expression of autoimmune antibodies against pancreatic interstitial structure in different stages of acute pancreatitis and to analyze its possible significance. Methods The clinical cases were analyzed by venous blood on the 1st, 2nd, the 4th and 7th day after the onset of illness. The anti-pancreatic mesenchymal antibodies in blood samples were analyzed by indirect immunofluorescence. And determination of urinary amylase and observation of clinical signs of change. Results As the course of the disease progressed, the positive expression rate of the antibody gradually increased (P <0.05), and the positive rate of the antibody increased with the improvement of the clinical symptoms (r = 0.996) and the biochemical indexes The recovery was positively correlated (r = 0.95 1). Conclusions Increased autoantibody expression is gradually detected in the convalescent serum of patients with acute pancreatitis, which is directed primarily at the interstitial structure of the pancreas and may play a protective role in the course of pancreatitis