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目的观察硝普钠、尼卡地平治疗恶性高血压的降压效果及效价比。方法36例恶性高血压患者随机分成两组,一组持续静脉泵入硝普钠,另一组持续静脉泵入尼卡地平作为对照,监测血压,观察两组治疗效果,同时了解达到治疗恶性高血压的最初目标的医疗费用。结果硝普钠、尼卡地平可显著降低恶性高血压患者的血压,两组治疗前后比较,其血压差异具有高度选择性(P<0.01),两种药物疗效无显著性差异(P>0.05),都能达到治疗的最初目标,硝普钠达到目标的费用明显低于尼卡地平组。结论硝普钠对恶性高血压有显著疗效,价廉物美,当为首选。
Objective To observe the antihypertensive effect and potency ratio of sodium nitroprusside and nicardipine in treating malignant hypertension. Methods Thirty-six patients with malignant hypertension were randomly divided into two groups: one was continuous intravenous injection of sodium nitroprusside, the other was continuous intravenous infusion of nicardipine as a control, blood pressure was monitored, and the therapeutic effect was observed. Medical costs of the initial goal of blood pressure. Results Sodium nitroprusside and nicardipine could significantly reduce the blood pressure in patients with malignant hypertension. Before and after treatment, the differences in blood pressure were highly selective (P <0.01). There was no significant difference between the two drugs (P> 0.05) , Can achieve the initial goal of treatment, sodium nitroprusside cost significantly lower than the nicardipine group. Conclusion Sodium nitroprusside has a significant effect on malignant hypertension, cheap, when the preferred.