肝纤维化是由多种病因引起的肝脏疾病普遍的病理过程,是肝脏细胞外基质(extracellular matrix,ECM)生成与降解失衡,进而导致肝脏内纤维结缔组织异常沉积的结果。肝星状细胞(hepatic stellate cell,HSC)的激活是肝纤维化的中心事件,多种细胞因子参与这一过程,当促纤维化因子与抗纤维化因子的作用发生失衡,而最终促纤维化因子占据优势导致肝纤维化发生。本文简要综述肝纤维化相关的重要细胞因子及发生作用的信号通路。 Liver fibrosis is a common pathological process of liver diseases caused by various causes. It is an imbalance in the formation and degradation of the extracellular matrix (ECM) in the liver, leading to the abnormal deposition of fibrous connective tissue in the liver. Activation of hepatic stellate cells (HSCs) is a central event in hepatic fibrosis. A variety of cytokines are involved in this process. When the action of pro-fibrotic factors and antifibrotic factors is unbalanced, the eventual promotion of fibrosis Factors occupy the advantage lead to liver fibrosis. This article briefly reviews the important cytokines and pathways involved in liver fibrosis.