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目的探讨同型半胱氨酸(Homocysteine,Hcy)与中青年脑梗死患者及其病情的相关性。方法共纳入85例经头颅MRI/CT证实的中青年脑梗死患者,同时从门诊随机抽取90例无动脉粥样硬化病史的人群作为对照组。入院24h内行美国国立卫生院神经功能缺损评分(The National Institutes of Health Stroke Scale,NIHSS)。采用酶联免疫吸附法检测血清HCY水平。结果与正常对照组相比,中青年脑梗死患者的Hcy水平明显增高,差异比较有统计意义(P﹤0.05);中青年脑梗死患者诊断为HH的例数亦高于对照组,差异比较有统计意义(P﹤0.05)。进一步行血清Hcy水平与病情的关系分析结果显示,随着NIHSS评分的严重程度的增加,血清Hcy水平亦随之升高,呈正相关,相关系数为0.92(P﹤0.05);随着NIHSS评分的严重程度的增加,诊断为HH的患者比例亦随之升高,但差异比较无统计学意义(P﹥0.05)。结论血清Hcy水平与中青年脑梗死的发生存在密切相关性,且可以反映脑梗死灶的大小及病情的严重程度。血清Hcy水平与脑梗死的病情呈明显正相关关系。对该类患者的血清Hcy水平需要进行严格的控制,可能降低中青年脑梗死的发生率并改善预后。
Objective To investigate the relationship between Homocysteine (Hcy) and young patients with cerebral infarction and its condition. Methods A total of 85 middle-aged and young patients with cerebral infarction confirmed by head MRI / CT were enrolled. At the same time, 90 patients with no history of atherosclerosis were selected randomly as the control group. The National Institutes of Health Stroke Scale (NIHSS) was performed within 24 hours of admission. Serum HCY levels were measured by enzyme-linked immunosorbent assay. Results Compared with the normal control group, the level of Hcy in young and middle-aged patients with cerebral infarction was significantly higher (P <0.05), and the number of cases diagnosed as HH in young and middle-aged patients with cerebral infarction was also higher than that in the control group Statistical significance (P <0.05). Further analysis of the relationship between the serum Hcy level and the disease showed that with the increase of the severity of NIHSS, the level of serum Hcy also had a positive correlation with the correlation coefficient of 0.92 (P <0.05). With the NIHSS score The severity of the increase in the proportion of patients diagnosed with HH also increased, but the difference was not statistically significant (P> 0.05). Conclusion Serum Hcy levels are closely related to the occurrence of cerebral infarction in middle-aged and young adults, and can reflect the size of cerebral infarction and the severity of the disease. Serum Hcy levels and cerebral infarction showed a significant positive correlation between the disease. Serum Hcy levels in these patients need to be rigorously controlled and may reduce the incidence of cerebral infarction in young and middle-aged patients and improve prognosis.