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目的对比分析埃索美拉唑与奥美拉唑治疗胃溃疡的临床疗效。方法收集我院2010年2月~2015年1月诊治的158例胃溃疡患者作为研究对象，根据患者的治疗药物将其分为埃索美拉唑组(79例)与奥美拉唑组(79例)，奥美拉唑组采用奥美拉唑+克拉霉素缓释片+阿莫西林克拉维酸钾治疗，埃索美拉唑组采用埃索美拉唑+克拉霉素缓释片+阿莫西林克拉维酸钾治疗，观察两组患者的总体治疗效果、幽门螺杆菌根除率及复发率。结果埃索美拉唑组患者的总体治疗效果和幽门螺杆菌根除率均明显高于奥美拉唑组(<0.05)。在为期一年的随访中，埃索美拉唑组仅有4例患者复发，复发率为5.06%，奥美拉唑组有15名患者复发，复发率为18.99%，埃索美拉唑组的复发率明显低于奥美拉唑组(<0.05)。结论埃索美拉唑治疗胃溃疡的临床疗效优于奥美拉唑。“,”Objective To compare and analyze the clinical ef ects of esomeprazole and omeprazole triple therapies on gastric ulcer. Methods 158 patients who suf ered from the gastric ulcer and who accepted treatments in our hospital from February, 2010 to January, 2015 were taken as the research objects, and these patients were according the the drug randomly divided into esomeprazole group (79 cases) and omeprazole group (79 cases). In the omeprazole group , they were treated with the omeprazole, clarithromycin sustained release tablets and amoxicil in clavulanic acid potassium while in the esomeprazole group, they were treated with the esomeprazole , clarithromycin sustained release tablets and amoxicil in and clavulanate potassium. Then, the overal treatment ef ect, helicobacter pylori eradication rate and recur ence rate of these two groups of patients were observed. Results The overal treatment ef ect and Helicobacter pylori eradication rate in esomeprazole group were significantly higher than those in omeprazole group ( <0.05). During the one-year fol ow-up, esomeprazole group only 4 patients were recur ed and the recurrence rate was 5.06%, while in the omeprazole group that had 15 patients were recur enced,the recurrence rate was 18.99%, which the recur ence rate in the esomeprazole group was evidently lower than the omeprazole group ( <0.05). Conclusion The clinical ef ects of esomeprazole is superior to omeprazole in treatment of gastric ulcer.