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目的:探讨多发性骨髓瘤(MM)的主要临床特点以及骨髓细胞形态学在MM诊断中的作用。方法:回顾分析130例MM患者临床特点并分析其骨髓及外周血涂片,观察骨髓瘤细胞的比例和形态特征。结果:130例MM患者临床表现中主要有贫血99例(76.2%)、骨痛81例(62.3%)、骨质破坏83例(63.8%)、肾功能损害70例(53.8%)、出血6例(4.6%)等。骨髓涂片中骨髓瘤细胞比例≥10%的126例(96.9%),骨髓瘤细胞比例在6.0%～10.0%的3例(2.3%),骨髓瘤细胞比例不增高的1例(0.7%)。结论:MM的诊断中,骨髓细胞形态学是非常重要的方法,但同时需结合临床表现及影像学、生化等方法。
Objective: To investigate the main clinical features of multiple myeloma (MM) and the role of bone marrow cell morphology in the diagnosis of MM. Methods: A retrospective analysis of 130 cases of MM patients with clinical features and analysis of bone marrow and peripheral blood smears, observe the proportion of myeloma cells and morphological characteristics. Results: The clinical manifestations of 130 patients with MM mainly included anemia in 99 cases (76.2%), bone pain in 81 cases (62.3%), bone destruction in 83 cases (63.8%), renal dysfunction in 70 cases (53.8% Cases (4.6%) and so on. There were 126 cases (96.9%) with myeloma cells ≥10%, 3 cases (2.3%) with myeloma cells 6.0% -10.0%, and 1 case (0.7%) with no increase of myeloma cells. . Conclusion: In the diagnosis of MM, myeloid cell morphology is a very important method, but at the same time it needs to combine with clinical manifestations, imaging, biochemistry and other methods.