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熟悉药代动力学有 利于正确处方 PDE5抑制剂 使药物达到比较好的疗效的秘密在于熟悉此药物的药代动力学,3种PDE5抑制剂的达峰时间和半衰期见表1。其中西地那非的最大优势在于患者服用后药物吸收曲线相似,重复性好,可信度高,因而具有可预知性(图1,2)。服用西地那非达到最大峰浓度的时间是0.5-2小时,达到平均最大峰浓度时间是1小时。在这一点上,西地那非和伐地那非的时间是相似的,同时半衰期也相似。从起效时间来看。服用西地那非的患者有35％在第14分钟就发生作用。在比较低的血药浓度,只有心理性ED患者和轻度ED患者会有反应。对中度和重度ED患者要达到82％有效率,需要很高的血药
Familiar with pharmacokinetics is conducive to the correct prescription PDE5 inhibitors make the drug to achieve better efficacy of the secret lies in familiar with the drug pharmacokinetics, three kinds of PDE5 inhibitor peak time and half-life in Table 1. One of the biggest advantages of sildenafil is the patient after taking similar absorption curve, good repeatability, high credibility, and therefore predictable (Figure 1,2). The time taken to reach the maximum peak concentration with sildenafil was 0.5 to 2 hours and the average maximum peak concentration time was 1 hour. The timing of sildenafil and vardenafil at this point is similar, with similar half-lives. From the onset time of view. 35% of patients taking sildenafil took effect on the 14th minute. At lower plasma concentrations, only patients with psychogenic ED and those with mild ED respond. To moderate and severe ED patients to achieve 82% efficiency, requires high blood medicine