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目的:观察DNA免疫吸附柱对狼疮性肾炎患者的临床疗效。方法:选择16例活动性狼疮性肾炎患者,采用DNA免疫吸附柱进行32例次血液吸附。观察相关症状及蛋白尿改善情况:ANA、ds-DNA清除效果;血常规、肝、肾功能、电解质、免疫球蛋白等影响程度。结果:吸附后症状明显改善,尿蛋白减轻;ANA水平显著下降(P=0.0001),ds-DNA抗体完全清除;血中有形成份、肝、肾功能、电解质等无明显影响。结论:DNA免疫吸附的净化疗法是治疗狼疮性肾炎特异性相对较强、疗效好、无明显毒副反应的一种新疗法。
Objective: To observe the clinical effect of DNA immunoadsorbent column on patients with lupus nephritis. Methods: Sixteen patients with active lupus nephritis were selected and 32 cases of blood samples were adsorbed by DNA immunosorbent column. Observe the relevant symptoms and proteinuria to improve: ANA, ds-DNA scavenging effect; blood, liver, kidney function, electrolytes, immunoglobulins and other effects. Results: After the treatment, the symptoms were obviously improved and the urinary protein was reduced. The level of ANA was significantly decreased (P = 0.0001). The ds-DNA antibody was completely eliminated. There was no obvious effect on the blood components, liver, kidney function and electrolytes. Conclusion: The purification of DNA immunoadsorption is a new therapy for the treatment of lupus nephritis with relatively strong specificity, good curative effect and no obvious side effects.