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目的 :通过电刺激迷走神经观察植入式闭环芯片系统对清醒兔心率的调控作用。方法 :将12只心率正常的新西兰兔随机分2组:对照组、迷走神经电刺激(vagus nerve stimulation,VNS)组。VNS组兔体内植入自主研发的闭环芯片1周,随机电刺激右侧迷走神经1 h,恢复1 h;对照组体内植入无刺激的芯片。MD2000WL软件记录实时心电图(electrocardiogram,ECG),芯片根据ECG计算心率。结果:植入式闭环芯片可在清醒兔体内工作。芯片可以成功记录完整心电图。VNS组调控期间心率明显低于调控前的基础心率[(265.2±15.2)次/min vs.(289.5±15.7)次/min,P<0.05]。VNS组调控期间心率和对照组相比较,VNS组的心率明显降低[(-24.3±3.6)次/min vs.(-4.6±5.1)次/min,P<0.05]。结论:植入式闭环芯片系统可以长期调控清醒兔的心率。
OBJECTIVE: To observe the effect of implantable closed loop system on the heart rate of conscious rabbits by electrically stimulating the vagus nerve. Methods: Twelve New Zealand rabbits with normal heart rate were randomly divided into two groups: control group, vagus nerve stimulation (VNS) group. The VNS group was implanted with a self-developed closed-loop chip for 1 week, randomly stimulated the right vagus nerve for 1 hour and recovered for 1 hour. The control group was implanted with non-stimulated chip. MD2000WL software records real-time ECG (electrocardiogram, ECG), the chip based on ECG calculation of heart rate. Results: Implantable closed-loop chips can work in awake rabbits. Chip can successfully record the complete ECG. Heart rate was significantly lower during VNS regimen than before regimen (265.2 ± 15.2 strokes / min vs. 289.5 ± 15.7 strokes / min, P <0.05). Heart rate was significantly lower in the VNS group than in the control group during VNS regimen ([-24.3 ± 3.6] beats / min vs. (-4.6 ± 5.1) beats / min, P <0.05). Conclusion: The implantable closed loop system can regulate the heart rate of conscious rabbits for a long time.