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目的观察咽异感症患者的胃食管反流情况,评估胃食管反流在咽异感症病因学及临床表现中的作用。方法按罗马Ⅱ标准,对26例咽异感症患者进行食管内24 h动态pH和胆汁监测,然后进行7 d的埃索美拉唑(耐信)试验治疗,并选择26例同期年龄、性别相匹配的胃食管反流病患者进行对照。结果观察组发生病理性反流者咽异感症8例(30.8%),对照组17例(65.4%),两组比较差异有统计学意义(P<0.05)。埃索美拉唑治疗后咽异感症7例症状消失,10例症状减轻,有效率65.4%。对照组13例症状消失,9例症状减轻,有效率84.6%。两组比较差异无统计学意义(P>0.05)。结论部分咽异感症患者存在病理性胃食管反流,用抑酸治疗有效,提示病理性胃食管反流可能是咽异感症的病因之一。
Objective To observe the gastroesophageal reflux disease in patients with pharyngeal syndrom and to evaluate the role of gastroesophageal reflux disease in the etiology and clinical manifestations of pharyngeal abnormalities. Methods Twenty-six patients with pharyngeal dysarthria underwent esophageal 24 h dynamic pH and bile monitoring according to the standard of Rome Ⅱ, and then treated with esomeprazole for 7 days. Twenty-six patients with the same age and sex matched Gastroesophageal reflux disease patients were controlled. Results There were 8 cases (30.8%) of the patients with pathologic reflux in the observation group and 17 cases (65.4%) in the control group. There was significant difference between the two groups (P <0.05). After esomeprazole treatment, 7 cases of symptoms of pharyngeal abnormalities disappeared, 10 cases of symptoms alleviated, the effective rate was 65.4%. The control group, 13 cases of symptoms disappeared, 9 cases alleviate the symptoms, the effective rate was 84.6%. There was no significant difference between the two groups (P> 0.05). Conclusions There is pathological gastroesophageal reflux disease in patients with partial pharyngeal sensation and the treatment with acid suppression is effective, suggesting that pathological gastroesophageal reflux may be one of the causes of pharyngeal heterosis.