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应用放射受体分析法测定305例Graves病患者的血清TRAb活性。甲亢未控制组的TRAb阳性率(94.7％)和抑制率(47.1±2.2％,S_r)均显著高于甲亢控制组(分别为33.7％和13.6±1.9％,S_r)。32例甲亢复发组的TRAb阳性率(96.9％)和抑制率(50.1±26.2％)亦显著高于54例甲亢缓解组。38例Graves病经停药后随访8～30个月,16例TRAb阳性者中有12例复发,而22例TRAb阴性者仅6例复发,复发率显著低于TRAb阳性者(P<0.05)。复发患者的TRAb活性较复发前升高(P<0.05)。临床观察表明TRAb活性高者容易且较早复发。6例Graves病经甲状腺手术后8～14个月,TRAb均转为阴性,并保持甲亢临床缓解状态。
Determination of serum TRAb activity in 305 patients with Graves’ disease by radioimmunoassay. The positive rate of TRAb (94.7%) and inhibition rate (47.1 ± 2.2%, S_r) in uncontrolled hyperthyroidism group were significantly higher than those in hyperthyroidism control group (33.7% and 13.6 ± 1.9%, respectively). The positive rate of TRAb (96.9%) and the inhibition rate (50.1 ± 26.2%) in 32 cases of hyperthyroidism recurrence group were also significantly higher than those of 54 cases of hyperthyroidism remission group. Thirty-eight patients with Graves’ disease were followed up for 8-30 months after drug withdrawal. Twelve of 16 patients with TRAb-positive relapse, while only 6 of 22 patients with TRAb-negative relapse, the recurrence rate was significantly lower than that of TRAb-positive patients (P <0.05) . TRAb activity in relapsed patients was higher than before relapse (P <0.05). Clinical observation shows that TRAb activity is easy and early recurrence. 6 cases of Graves disease after thyroid surgery 8 to 14 months, TRAb turned negative, and maintain the clinical remission of hyperthyroidism.