通过小鼠骨髓染色体畸变和小鼠精子畸形试验，对苯酚的遗传毒性进行了观察．结果在５０、１００、２００ｍｇ／ｋｇ体重３个剂量组中，染色体畸变率和畸变细胞百分率显著高于阴性对照组，且有统计学意义．在相同剂量范围内与阴性对照组相比，小鼠精子畸形百分率未有显著性差异。结合国外有关报道，可以认为苯酚是一种具有遗传毒性的诱变剂。长期职业接触可能会对作业工人产生远期危害． Genotoxicity of phenol was observed by chromosomal aberrations in mouse bone marrow and mouse sperm abnormality test. Results In the three dose groups of 50, 100, and 200 mg / kg body weight, the chromosome aberration rate and the percentage of aberrant cells were significantly higher than those of the negative control group, with statistical significance. In the same dose range compared with the negative control group, the percentage of mice sperm deformity was not significantly different. Combined with foreign reports, we can think that phenol is a genotoxic mutagen. Long-term occupational exposure may have long-term hazards to workers.