以氰化钠、2,2,2-三氟苯乙酮、乙酸酐为原料,通过亲核及酯化反应合成了标题化合物。实验考察了无水四氢呋喃、无水硝基甲烷溶剂对反应的影响,结果表明该反应在四氢呋喃溶剂中常温下即可顺利进行,且副产物较少,产率为76.3%。提纯后的化合物经NMR、HPLC-TOF/MS和GC-EI/MS进行结构表征,并考察了该化合物在不同溶剂中的稳定性及低浓度氰化钠衍生为目标化合物的衍生效率。 The title compound was synthesized by nucleophilic and esterification using sodium cyanide, 2,2,2-trifluoroacetophenone and acetic anhydride as starting materials. The effects of anhydrous tetrahydrofuran and anhydrous nitromethane on the reaction were investigated experimentally. The results showed that the reaction proceeded smoothly at room temperature in tetrahydrofuran solvent with less by-products and the yield was 76.3%. The purified compounds were characterized by NMR, HPLC-TOF / MS and GC-EI / MS. The stability of the compounds in different solvents and the derivatization efficiency of the target compound derived from low concentration sodium cyanide were investigated.